About
The GHZ Lab works at the interface between life, physics, chemistry, math, and engineering to “quantitatively” understand outstanding problems of living matter in order to improve human health. We are located at the University of Houston where we are proud to have created an inclusive, collaborative, interdisciplinary, and open-minded Lab.
Theory, Simulation, and Computation in Biomolecular Science
At the GHZ Lab, we explore the fundamental principles governing biomolecular behavior using advanced computational approaches. Our research lies at the intersection of molecular thermodynamics, multiscale modeling, and soft matter physics, with a strong emphasis on protein-RNA interactions, biomolecular phase transitions, complex coacervate stability, and transcriptional condensates.
We leverage theoretical frameworks, data-driven approaches, and state-of-the-art simulation techniques, including molecular dynamics, Monte Carlo, and enhanced sampling methods to uncover the mechanisms driving macromolecular assembly, nucleation, and structural transitions. Our work has broad implications, ranging from decoding the complexity of human gene expression to designing novel biomaterials and therapeutics.
